GLG1 Protein

Catalog No. ABIN1589741

This Recombinant GLG1 protein is produced in Escherichia coli (E. coli).

Quick Overview for GLG1 Protein (ABIN1589741)

Target: GLG1 (Golgi Glycoprotein 1 (GLG1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % by SDS-PAGE. Visualized by silver stain

Product Details

Sequence: MTLQEAKEHR VSLKCRRQLR VEELEMTEDI RLEPDLYEAC KSDIKNFCSA VQYGNAQIIE CLKENKKQLS TRCHQKVFKL QETEMMDPEL DYTLMRVCKQ MIKRFCPEAD SKTMLQCLKQ NKNSELMDPK CKQMITKRQI TQNTDYRLNP MLRKACKADI PKFCHGILTK AKDDSELEGQ VISCLKLRYA DQRLSSDCED QIRIIIQESA LDYRLDPQLQ LHCSDEISSL CAELEHHHHH H

Characteristics: Length (AA): 241

Application Details

Application Notes: No biological data available at the moment.

Comment:

Soluble Receptors

Restrictions: For Research Use only

Handling

Format: Lyophilized

Storage: -20 °C/-80 °C

Storage Comment: The material is stable for greater than six months at -20° C to -70° C. After the first thawing it is recommended to aliquote the material, because repeated freeze-thaw cycles will decrease the activity.

Expiry Date: 6 months

Target Details

Target: GLG1 (Golgi Glycoprotein 1 (GLG1))

Alternative Name: ESL-1

Background: E-Selectin ligand 1/ESL 1 (GLG1, Golgi complex-Localized Glycoprotein 1, also CFR1, MG160 and Cysteine-rich FGF receptor) is a 150-160 kDa glycoprotein. The amino acid sequence of MG160, a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus, is more than 90 % identical with CFR, a fibroblast growth factor (FGF) binding protein of chicken membranes, and with ESL-1, a ligand for E-selectin of plasma membranes of myeloid cells, furthermore, MG160, isolated by immunoaffinity chromatography from rat brain membranes, binds to basic FGF. The gene for MG160 has been assigned to human chromosome 16q22-23. The protein has a large luminal domain composed of an initial Proline-Glutamine-rich segment, encoded by an uninterrupted exonic sequence of several CAG-CAA repeats. Expansion of CAG repeats has been implicated in the etiology of several neurodegenerative diseases. The Proline-Glutamine-rich segment is followed by 16 cysteine-rich repeats that contain five potential Asparagine-linked glycosylation sites, which are conserved in the human, rat, mouse, and chicken. The large extracellular domain of the protein is followed by a single transmembrane domain and a 13-amino-acid cytoplasmic carboxy-terminal tail, which is identical to that in the chicken, rat, and mouse. It is expressed in both Golgi and/or the cell membrane of multiple cell typs, including liver stellate cells, neurons, cardiac myocytes, monocytes and bronchial epithelial cells. In the blood, GLG1/ESL-1 collaborates with PSGL-1 to mediate leukocyte binding to endothelial cell surfaces.
Synonyms: Golgi apparatus protein-1, E-selectin ligand-1, Cysteine-rich fibroblast growth factor receptor

Molecular Weight: 28.34 kDa

NCBI Accession: NP_001139138, NM_001145666

UniProt: Q92896